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When comparing the experimental and FEA stress ratio of the PEEK stem, it has shown that the experimental stress ratio of the PEEK stem in strain gauges M1 and L1 are significantly larger than the FEA stress ratio. On the other hand, the stress ratio of PEEK stem in strain gauges M2, L2, and L3 have extremely low stress ratio in the experimental study in comparison to the FEA stress ratio. These deviations between the experimental and FEA study are caused due to slight geometrical mismatch of the printed PEEK stem with the Sawbone. Limitation in manufacturing precision is known to be the cause of this geometrical mismatch which prevents full contact of the PEEK stem to the surrounding cortical bone. Figure 4 shows the X-ray images of implanted Ti6Al4V and PEEK stems inside the Sawbone. Although both Ti6Al4V and PEEK stems were produced based on the same CAD model, the Ti6Al4V stem is tightly in touch with the Sawbone. While in the PEEK stem, a small gap is visible between the stem and the Sawbone cortical shell in the distal part, in M2, L2, and L3 regions. The loose contact in M2, L2, and L3 leads to the low surface stress in these points and large stress concentration in M1 and L1, which carry the load that is supposed to be taken from the loosely contacted part of the femur.

The London model describes strongly type-2 superconductors as massive vector field theories, where the magnetic field decays exponentially at the length scale of the London penetration length. This also holds for isotropic multiband extensions, where the presence of multiple bands merely renormalizes the London penetration length. We show that, by contrast, the magnetic properties of anisotropic multiband London models are not this simple, and the anisotropy leads to the interband phase differences becoming coupled to the magnetic field. This results in the magnetic field in such systems having N +1 penetration lengths, where N is the number of field components or bands. That is, in a given direction, the magnetic field decay is described by N +1 modes with different amplitudes and different decay length scales. For certain anisotropies we obtain magnetic modes with complex masses. That means that magnetic field decay is not described by a monotonic exponential increment set by a real penetration length but instead is oscillating. Some of the penetration lengths are shown to diverge away from the superconducting phase transition when the mass of the phase-difference mode vanishes. Finally the anisotropy-driven hybridization of the London mode with the Leggett modes can provide an effectively nonlocal magnetic response in the nominally local London model. Focusing on the two-component model, we discuss the magnetic field inversion that results from the effective nonlocality, both near the surface of the superconductor and around vortices. In the regime where the magnetic field decay becomes nonmonotonic, the multiband London superconductor is shown to form weakly-bound states of vortices.

This Husserlian phenomenological study explored the lived experience of eight full-time agency nurses working in the environment of intensive care in London, United Kingdom. In-depth interviews were used to ascertain the participants' experiences of full-time agency nursing in intensive care. Colaizzi's [Colaizzi P. Psychological research as the phenomenologist views it. In: Vale R, King M, editors. Existential-phenomenological alternatives for psychology. London: Oxford University Press; 1978, p. 48-71] method of data analysis was utilised. Thematic analysis identified three cluster themes: the shared experience of lacking confidence; the shared experience of deskilling; and the shared experience of feelings of isolation. The theme of the shared experience of lacking confidence identified the importance of support and understanding of agency nurses' needs in the ICU. The theme of the shared experience of deskilling illuminated participants concern at not having the opportunity to care for patients of higher acuity. The theme of the shared experience of feelings of isolation highlighted that often participants did not feel they "belonged to a team". Study findings suggest the need to include: the implementation of protocols within the clinical setting; the provision of performance feedback to agency nurses; and the consideration of ongoing structured professional development and education for ICU agency nurses.

We perform a multifractal analysis of the evolution of London's street network from 1786 to 2010. First, we show that a single fractal dimension, commonly associated with the morphological description of cities, does not suffice to capture the dynamics of the system. Instead, for a proper characterization of such a dynamics, the multifractal spectrum needs to be considered. Our analysis reveals that London evolves from an inhomogeneous fractal structure, which can be described in terms of a multifractal, to a homogeneous one, which converges to monofractality. We argue that London's multifractal to monofractal evolution might be a special outcome of the constraint imposed on its growth by a green belt. Through a series of simulations, we show that multifractal objects, constructed through diffusion limited aggregation, evolve toward monofractality if their growth is constrained by a nonpermeable boundary.

In 1889, when Dr John Bland-Sutton, a prominent surgeon in London, England, was consulted concerning fatal rickets in more than 20 successive litters of lion cubs at the London Zoo, he evaluated the role of diet relative to the development of rickets. He prescribed goat meat and bones and cod-liver oil to be added to the lean horse-meat diet of the cubs and their mothers. Rickets reversed, the cubs survived, and litters were reared successfully. In classic controlled studies conducted in puppies and young rats 3 decades later, the crucial role of calcium, phosphate, and vitamin D in both prevention and therapy of rickets was elucidated. Later studies led to the identification of the structural features of vitamin D. Although the Bland-Sutton interventional diet obviously provides calcium and phosphate from bones and vitamin D from cod-liver oil, other benefits of this diet were not initially recognized. Chewing bones promotes tooth and gum health and removes bacteria-laden tartar. Cod-liver oil also contains vitamin A, which is essential for the prevention of infection and for epithelial cell health. Taurine-conjugated bile salts are also necessary for the intestinal absorption of fat-soluble vitamins, including A and D. Moreover, unlike dogs and rats, all feline species are unable to synthesize taurine yet can only conjugate bile acids with taurine. This sulfur-containing beta-amino acid must be provided in the carnivorous diet of a large cat. Taurine-conjugated bile salts were provided in the oil cold-pressed from cod liver. The now famous Bland-Sutton "experiment of nature," namely, fatal rickets in lion cubs, was cured by the addition of minerals and vitamin D. However, gum health and the presence of taurine-conjugated bile salts undoubtedly permitted absorption of vitamin A and D, the latter promoting the cure of rickets.

Until relatively recently, many authors have assumed that if extraterrestrial life is discovered it will be via the discovery of extraterrestrial intelligence: we can best try to detect life by adopting the SETI approach of trying to detect beacons or artefacts. The Rio Scale, proposed by Almár and Tarter in 2000, is a tool for quantifying the potential significance for society of any such reported detection. However, improvements in technology and advances in astrobiology raise the possibility that the discovery of extraterrestrial life will instead be via the detection of atmospheric biosignatures. The London Scale, proposed by Almár in 2010, attempts to quantify the potential significance of the discovery of extraterrestrial life rather than extraterrestrial intelligence. What might be the consequences of the announcement of a discovery that ranks low on the London Scale? In other words, what might be society's reaction if 'first contact' is via the remote sensing of the byproducts of unicellular organisms rather than with the products of high intelligence? Here, I examine some possible reactions to that question; in particular, I discuss how such an announcement might affect our views of life here on Earth and of humanity's place in the universe.

dispersed downwind, with peak concentrations displaced from the urban centre along the main wind direction. The urban-regional surface CO2 flux was calculated for four days in October 2011 by either the Integrative Mass Boundary Layer (IMBL) or the Column Integration method (CIM), dependent on meteorological conditions. The diurnal CO2 flux in London obtained from the aircraft observations ranged from 36 to 71 μmol CO2 m-2 s-1 during the day time. This compared well with continuous measurements of CO2 exchange by an eddy-covariance system located in central London. The day-to-day variability observed in the calculated CO2 fluxes responded to the spatial variability of the influence area and emissions that observations were sensitive to. This study provides an example how aircraft surveys in urban areas can be used to estimate CO2 surface fluxes at the urban-regional scale. It also presents an important cross-validation of two independent measurement-based methods to infer the contribution of urban areas to climate change in terms of CO2 emissions that complement bottom-up emissions inventories. References Committee on Methods for Estimating Greenhouse Gas Emissions (2010), The National Academia Press. DECC (2012),

We investigate the growth dynamics of Greater London defined by the administrative boundary of the Greater London Authority, based on the evolution of its street network during the last two centuries. This is done by employing a unique dataset, consisting of the planar graph representation of nine time slices of Greater London's road network spanning 224 years, from 1786 to 2010. Within this time-frame, we address the concept of the metropolitan area or city in physical terms, in that urban evolution reveals observable transitions in the distribution of relevant geometrical properties. Given that London has a hard boundary enforced by its long standing green belt, we show that its street network dynamics can be described as a fractal space-filling phenomena up to a capacitated limit, whence its growth can be predicted with a striking level of accuracy. This observation is confirmed by the analytical calculation of key topological properties of the planar graph, such as the topological growth of the network and its average connectivity. This study thus represents an example of a strong violation of Gibrat's law. In particular, we are able to show analytically how London evolves from a more loop-like structure, typical of planned cities, toward a more tree-like structure, typical of self-organized cities. These observations are relevant to the discourse on sustainable urban planning with respect to the control of urban sprawl in many large cities which have developed under the conditions of spatial constraints imposed by green belts and hard urban boundaries. 2b1af7f3a8